Striking a Balance: Medical Ethics Insights on Treating Cervical Cancer in Pregnancy with Reduced Standard Radiation via IMRT
Roland M. Panaligan
Oct 2025 DOI 10.35460/2546-1621.2025-0232 Access
Abstract
Cervical cancer during pregnancy poses a rare and complex clinical and ethical challenge, particularly in low- and middle-income countries such as the Philippines. The dual obligation to preserve maternal life while protecting fetal viability requires a nuanced balance between medical science, ethics, and cultural values. This commentary explores the ethical implications of treating cervical cancer in pregnancy using Intensity Modulated Radiation Therapy (IMRT) at reduced standard radiation volumes, highlighting how medical innovation intersects with the principles of biomedical ethics.
Keywords: cervical cancer in pregnancy, IMRT, biomedical ethics, autonomy, beneficence, non-maleficence, justice, ethical decision-making, fetal safety, shared decision-making
- Le Guévelou J, Selleret L, Laas E, Lecuru F, Kissel M. Cervical cancer associated with pregnancy: Current challenges and future strategies. Cancers (Basel) [Internet]. 2024;16(7):1341. Available from: http://dx.doi.org/10.3390/cancers16071341 . PMID: 38611019; PMCID: PMC11011172.
- Buonomo B, Orecchia R, Tomao F, Pup LD, Garcia-Faura A, Peccatori FA. Uterine irradiation as a determinant of infertility and pregnancy losses in young cancer survivors. Ecancermedicalscience [Internet]. 2020;14:1032. Available from: http://dx.doi.org/10.3332/ecancer.2020.1032 .
- Kal HB, Struikmans H. Radiotherapy during pregnancy: fact and fiction. Lancet Oncol [Internet]. 2005;6(5):328–33. Available from: http://dx.doi.org/10.1016/S1470-2045(05)70169-8 .
- Beauchamp TL, Childress JF. Principles of Biomedical Ethics. 8th ed. Oxford: Oxford University Press; 2019.
- Malek J. Maternal decision-making during pregnancy: Parental obligations and cultural differences. Best Pract Res Clin Obstet Gynaecol [Internet]. 2017;43:10–20. Available from: http://dx.doi.org/10.1016/j.bpobgyn.2017.02.002
- Chervenak FA, McCullough LB. The ethics of maternal-fetal surgery. Semin Fetal Neonatal Med [Internet]. 2018;23(1):64–7. Available from: http://dx.doi.org/10.1016/j.siny.2017.09.008
- Alora RAT. Bioethics Learning Guide. Makati City, Philippines: Bookmark, Inc.; 2025.
- Vergara TVT, Chua TMC, Santi KMG, Magsanoc JMJ, Peña-Camacho A, Vega GP, et al. Radiation oncology in the Philippines: Current state and future directions. Adv Radiat Oncol [Internet]. 2024;9(2):101354. Available from: http://dx.doi.org/10.1016/j.adro.2023.101354 .
- Canal JPA, Eala MAB, Arevalo MVPN, Dee EC, Co HCS. Radiotherapy resources in the Philippines: A 2022 update. J Cancer Policy [Internet]. 2024;41(100485):100485. Available from: http://dx.doi.org/10.1016/j.jcpo.2024.100485 . PMID: 38768855.
- Daniels N. Just Health: Meeting Health Needs Fairly. Cambridge: Cambridge University Press; 2008.
- Li M, Zhao Y, Qie M, Zhang Y, Li L, Lin B, et al. Management of cervical cancer in pregnant women: A multi-center retrospective study in China. Front Med (Lausanne) [Internet]. 2020;7:538815. Available from: http://dx.doi.org/10.3389/fmed.2020.538815 .
- 75th WMA General Assembly [Internet]. Helsinki, Finland; 2024 Oct. Available from: https://www.wma.net/news-post/the-world-medical-association-general-assembly-2024-in-summary/
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