Aging and Immunity: Challenges, Insights and Breakthrough Solutions

Tommy C. Sim

Apr 2025 DOI 10.35460/2546-1621.2025-0017     Access   

Abstract

As global life expectancy rises, the aging population faces increasing health challenges, with immunosenescence (the gradual decline in immune function) being a critical concern. This decline is driven by mechanisms such as thymic involution, reduced B-cell function, impaired antigen presentation and chronic low-grade inflammation (inflammaging). These factors increase susceptibility to infections, reduce vaccine efficacy and contribute to chronic inflammatory diseases in older adults.

This review explores mechanisms of immunosenescence and potential interventions, including thymic rejuvenation, stem cell therapies, immune-modulating diets and exercise and advancements in vaccine technologies (eg, adjuvant-enhanced and mRNA vaccines). Focus is placed on immunological strategies for aging individuals, particularly in the context of COVID-19.

Challenges in combating immunosenescence include variability in immune responses among older adults and safety concerns with therapies like checkpoint inhibitors. The complex mechanisms of immune aging, especially in T cells, remain poorly understood. Personalized medicine offers promising solutions with gene editing technologies potentially repairing immune cells. However, traditional strategies such as exercise and proper nutrition remain crucial.

Developing biomarkers to track immune aging will enable early detection and personalized treatments. Addressing ethical, cultural and social factors is vital for equitable access and public acceptance of anti-aging treatments. Ultimately, a multidisciplinary approach combining personalized medicine, preventive strategies and immune-modulating therapies will enhance immune resilience, improve disease outcomes and promote healthier aging for older populations.

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